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Bruker BioSpec Maxwell Intelligent Preclinical MRI



Maxwell Magnet Technology

No liquid helium filling combined with 3 Tesla, 7 Tesla, and 9.4 Tesla field strengths

Self-monitoring

Push button auto-cooling and auto-charging for maximum uptime

Compact

Small footprint, self-shielded magnet for maximal siting possibilities in small and/or BSL areas


Detail

Maxwell Magnet Technology

Maxwell magnet technology makes superconducting Magnetic Resonance Imaging without the need for liquid cryogen filling possible. This revolutionary magnet technology is based on recondensing cooling of a minuscule volume of helium and a patented cooling technology . A powerful dual stage cold head maintains the low temperature of < 4.2 K, allowing constant recondensing of the helium, which in turn cools the superconducting coil.


  • Features superconducting magnet conduction cooling technology 

  • Eliminates liquid cryogen filling and the need for quench pipes 

  • Simplifies siting and maintenance 

  • Incorporates automatic self-supervision 

  • Empowers push-button magnet control

  • Enables most demanding studies

Brief Introduction

BioSpec Maxwell MRIs recreate preclinical MRI, taking operational ease of use to a new level. Cutting-edge autonomous instrument control continually self-regulates instrument parameters to their optimal state, providing a completely new ownership and imaging experience.

The BioSpec Maxwell MRI’s innovative Maxwell magnet technology eliminates the need for liquid helium filling, providing long-term cost savings and making use inherently safe.

With their small footprint and minimal site requirements, the BioSpec Maxwell MRIs perfectly fit into existing lab structures, expanding biomedical research capabilities with easy-to-use MRI.

The intuitive workflows ensure highest productivity for a wide range of preclinical MRI studies on small rodents.

While this simplicity guarantees best results, the flexibility of classic BioSpec features such as the method development platform and the possibility to add an MRI CryoProbe or PET module provide users with the unparalleled versatility and full range of freedom that is needed to push research boundaries.




Product Characteristics

1. Ease of Use and Maximal Productivity

  • Accurate animal positioning with the motorized Animal Transport System, including touchscreen operation even with gloves for a simplified, precise workflow

  • Intuitive ParaVision software with over 100 validated and ready to use in vivo protocols and scan programs for mice and rats

  • Streamlined workflows including automatic quantification

  • Safe operation with inherent shielding


2.  Maximum Cost Savings

  • No liquid helium or nitrogen fillings provides freedom from fluctuating helium prices

  • No Faraday cage required for easiest siting

  • No quench pipe required for easiest siting

  • Lightweight and compact footprint fits in any laboratory


3. Maximal Experimental Freedom

  • 3T, 7T, and 9.4T

  • Complete RF coil portfolio for mice and rats available including support for very large rats with best-in-class free RF-coil access of 82 mm

  • ParaVision software with more than 1,000 sequence variations including IntraGate based methods, UTE, and ZTE

  • Method development platform

  • Most advanced pulse-tube cold head for minimal vibrations for sensitive studies such as fMRI

  • Gradient strength up to 900 mT/m, Slew rate: 4200 T/m/s

  • Upgradable with MRI CryoProbe delivering an exceptional sensitivity increase

  • Upgradable with state-of-the-art PET insert or PET inline module


4. Maximal Reliability and Up-time

  • Hold-time minimum of 6 hours during cooling disruption1

  • Extensive sensors monitoring of instrument parameters

  • One-click charging and discharging

  • One-click cooling and warming


Application

1、Oncology

Spectroscopic imaging of hyperpolarized pyruvate and lactateconversion reveals intertumoral variation in patient derivedrenal cell carcinoma. 2D EPSI at 3T after infusion ofhyperpolarized [1-13c] pyruvate in mouse model.


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2、Drug Development

CEST imaging at 3T enables monitoring of compositionachanges of hydrogel-based drug treatment for glioblastomamultiforme (GBM), providing valuable insights for treatmentrefinement.


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3、Neurological Studies

FLASH angiography, such as this rat brain study at 7T can beused to investigate arterial abnormalities such as stenosisocclusions and aneurysms. Resolution in plane: (94 x 94)um2, Slice Thickness: 400 um, Slices: 80, Acquisition time: 08m 15 s


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Rat brain RARE at 7T, segmentation with pmod


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